Publications working group Anne Seidlitz



M. Wentzlaff M, V. Senz V, A. Seidlitz. Evaluation of the suitability of a fluidized bed process for the coating of drug-eluting stents. Eur. J. Pharm. Biopharm.  139 (2019) 85-92.

K. Pruessmann, M. Wentzlaff, R. Schilling, A. Seidlitz. Influence of dissolution vessel geometry and dissolution medium on in vitro dissolution behaviour of triamterene-coated model stents in different test setups. AAPS PharmSciTech 20 (2019) 27. 



S. Stein, S. Hadlich, S. Langner, A. Biesenack, N. Zehm, S. Kruschke, M. Oelze, M. Grimm, S. Mahnhardt, W. Weitschies, A. Seidlitz. 7.1 T MRI and T2 mapping of the human and porcine vitreous body post mortem. Eur. J. Pharm. Biopharm.  131 (2018)  82-91.

W. Kempin, V. Domsta, I. Brecht, B. Semmling, S. Tillmann, W. Weitschies, A. Seidlitz. Development of a dual extrusion printing technique for an acid- and thermo-labile drug. Eur. J. Pharm. Sci.  123 (2018) 191-198.

E. Wirthgen, W. Otten, M. Tuchscherer, A. Tuchscherer, G. Domanska, J. Brenmoehl, J. Günther, D. Ohde, W. Weitschies, A. Seidlitz, E. Scheuch, E. Kanitz. Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs. Int. J. Mol. Sci.  19 (2018) 3009.

W. Kempin, V. Domsta, G. Grathoff, I. Brecht, B. Semmling, S. Tillmann, W. Weitschies, A. Seidlitz. Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug. Pharm. Res.  35 (2018) 124. 

S. Stein, T. Auel, W. Kempin, M. Bogdahn, W. Weitschies, A. Seidlitz. Influence of the test method on in vitro drug release from intravitreal model implants containing dexamethasone or fluorescein sodium in poly (D,L-lactide-co-glycolide) or polycaprolactone. Eur. J. Pharm. Biopharm.  127 (2018) 270-278.



M. Probst, M. Schmidt, K. Tietz, S. Klein, W. Weitschies, A. Seidlitz. In vitro dissolution testing of parenteral aqueous solutions and oily suspensions of paracetamol and prednisolone. Int. J. Pharm. 532 (2017) 519-527.

W. Kempin, A. Baden, W. Weitschies, A. Seidlitz. Glycerol gelatin for 3D-printing of implants using a paste extrusion technique. Curr. Dir. Biomed. Engin. 3 (2017) 389-392.

S. Stein, M. Bogdahn, C. Rosenbaum, W. Weitschies, A. Seidlitz. Distribution of fluorescein sodium and triamcinolone acetonide in the simulated liquefied and vitrectomized Vitreous Model with simulated eye movements. Eur. J. Pharm. Sci. 109 (2017) 233-243.

W. Kempin, C. Franz, L.C. Koster, F. Schneider, M. Bogdahn, W. Weitschies, A. Seidlitz. Assessment of different polymers and drug loads for fused deposition modeling of drug loaded implants. Eur. J. Pharm. Biopharm. 115 (2017) 84-93

M. Probst, J.P. Kühn, C. Modeß, E. Scheuch, A. Seidlitz, N. Hosten, W. Siegmund, W. Weitschies. Muscle injury after intramuscular administration of diclofenac: A case report supported by magnetic resonance imaging. Drug Saf. - Case Rep.  4 (2017) 7



M. Probst, J.P. Kühn, E. Scheuch, A. Seidlitz, S. Hadlich, K. Evert, S. Oswald, W. Siegmund, W.  Weitschies. Simultaneous magnetic resonance imaging and pharmacokinetic analysis of  intramuscular depots. J. Control. Release 227 (2016) 1-12

S. Stein, M. Bogdahn, W. Weitschies, A. Seidlitz. Influence of Siluron(R) insertion on model drug distribution in the simulated vitreous body. Curr. Dir. Biomed. Engin. 2 (2016) 665-668 

M. Probst, M. Schmidt, W. Weitschies, A. Seidlitz. In vitro simulation of distribution processes following intramuscular injection. Curr. Dir. Biomed. Engin. 2 (2016) 383-386

E. Wirthgen, E. Kanitz, M. Tuchscherer, A. Tuchscherer, G. Domanska, W. Weitschies, A. Seidlitz, E. Scheuch, W. Otten. Pharmacokinetics of 1-methyl-L-tryptophan after single and  repeated subcutaneous application in a porcine model. Exp. Anim. 65 (2016) 147-155



W. Kempin, S. Kaule, T. Reske, N. Grabow, S. Petersen, S. Nagel, K.P. Schmitz, W. Weitschies,  A. Seidlitz. In vitro evaluation of paclitaxel coatings for delivery via drug-coated balloons. Eur. J. Pharm. Biopharm. 96 (2015) 322-328

S. Stein, C. Simroth-Loch, S. Langner, S. Hadlich, O. Stachs, N. Grabow, R. Guthoff, W.Weitschies, A. Seidlitz. MR imaging of model drug distribution in simulated vitreous. Curr. Dir. Biomed. Engin. 1 (2015) 236-239.

A. Seidlitz, W. Schick, T. Reske, V. Senz, N. Grabow, S. Petersen, S. Nagel, W. Weitschies. In vitro study of sirolimus release from a drug-eluting stent: Comparison of the release profiles obtained using different test setups. Eur. J. Pharm. Biopharm. 93 (2015) 328-338

A. Seidlitz, M. Wentzlaff, W. Weitschies. Controlling drug delivery from coronary stents - are we aiming for the right targets? Ther. Deliv. 6 (2015) 705-720



B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz. Impact of different tissue-simulating hydrogel compartments on in vitro release and distribution from drug-eluting stents. Eur. J. Pharm. Biopharm. 87 (2014) 570-578

A. Seidlitz. Dissolution testing of cardiologic drug-eluting medical devices. Pharm. Ind. 76 (2014) 1794-1800

M. Wentzlaff, A. Seidlitz, C. Harder, N. Grabow, W. Weitschies. Coating of stents with poly-L-lactide via fluidized-bed process. Biomed. Tech. 59 (2014) 841-844

A. Seidlitz, W. Kempin, T. Reske, S. Kaule, N. Grabow, S. Petersen, C. Harder, S. Nagel,. W. Weitschies. Evaluation of the influence of contact time and inflation pressure on drug transfer from drug-coated balloons. Biomed. Tech. 59 (2014) 375-378

C. Loch, M. Bogdahn, S. Stein, S. Nagel, R. Guthoff, W. Weitschies, A. Seidlitz. Simulation of Drug Distribution in the Vitreous Body After Local Drug Application into Intact Vitreous Body and in Progress of Posterior Vitreous Detachment. J. Pharm. Sci. 103 (2014) 517-526



A. Seidlitz, S. Nagel, B. Semmling, K. Sternberg, H. K. Kroemer, W. Weitschies. In Vitro Dissolution Testing of Drug-Eluting Stents. Curr. Pharm. Biotech. 14 (2013) 67-75

B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz. Development of Hydrophobized Alginate Hydrogels for the Vessel-Simulating Flow-Through Cell and Their Usage for Biorelevant Drug-Eluting Stent Testing. AAPS PharmSciTech. 14 (2013) 1209-1218

A. Seidlitz, N. Kotzan, S. Nagel, T. Reske, N. Grabow, C. Harder, S. Petersen, K. Sternberg, W. Weitschies. In vitro determination of drug transfer from drug-coated balloons. PLoS ONE 8 (2013) e83992

B. Semmling, S. Nagel, K. Sternberg, W. Weitschies, A. Seidlitz. Long-term stable hydrogels for biorelevant dissolution testing of drug-eluting stents. J. Pharm. Technol. Drug Res. 2 (2013) 19



A. Seidlitz, W. Weitschies. In-vitro dissolution methods for controlled release parenterals and their applicability to drug-eluting stent testing. J. Pharm. Pharmacol. 64 (2012) 969-985

K. Sternberg, M. Gratz, K. Koeck, J. Mostertz, R. Begunk, M. Loebler, B. Semmling, A. Seidlitz, P. Hildebrandt, G. Homuth, N. Grabow, C. Tuemmler, W. Weitschies, K. Schmitz, H. K. Kroemer. Magnesium used in bioabsorbable stents controls smooth muscle cell proliferation and stimulates endothelial cells in vitro. J. Biomed. Mater. Res. Part B 100 (2012) 41-50

C. Loch, S. Zakelj, A. Kristl, S. Nagel, R. Guthoff, W. Weitschies, A. Seidlitz. Determination of permeability coefficients of ophthalmic drugs through different layers of porcine, rabbit and bovine eyes. Eur. J. Pharm. Sci. 47 (2012) 131-138

C. Loch, S. Nagel, R. Guthoff, A. Seidlitz A, W. Weitschies. The Vitreous Model – a new in vitro test method simulating the vitreous body. Biomed. Tech. 57 (2012) 281-284

B. Semmling, A. Seidlitz, E. Trip, C. Schnittker, T. Reske, K. Sternberg, W. Weitschies. Examination of steroid release from screw-in pacing leads. Biomed. Tech. 57 (2012) 273-276

K. Sternberg, S. Petersen, N. Grabow, F. Luderer, A. Bohl, T. Reske, S. Siewert, I. Minrath, A. Seidlitz, W. Weitschies, H. Meyer zu Schwabedissen, H. K. Kroemer, K. P. Schmitz. Implant-associated local drug delivery systems for different medical applications. Biomed. Tech. 57 (2012) 393-396

M. Wentzlaff, A. Seidlitz, S. Nagel, C. Harder, C. Schnittker, E. Trip, T. Reske, K. Sternberg, W. Weitschies. Coating of collars via fluidised-bed process. Biomed. Tech. 57 (2012) 18-21

A. Seidlitz, S. Nagel, B. Semmling, S. Petersen, T. Reske, W. Schmidt, N. Grabow, K. Sternberg K, W. Weitschies. In vitro estimation of drug loss during the implantation procedure of drug-eluting stents. Biomed. Tech. 57 (2012) 403-406



A. Seidlitz, S. Nagel, B. Semmling, N. Grabow, H. Martin, V. Senz, C. Harder, K. Sternberg, K. Schmitz, H. K. Kroemer, W. Weitschies. Examination of drug release and distribution from drug-eluting stents with a vessel-simulating flow-through cell. Eur. J. Pharm. Biopharm. 78 (2011) 36-48

A. Seidlitz, S. Nagel, B. Semmling, N. Grabow, K. Sternberg, W. Weitschies. Biorelevant dissolution testing of drug-eluting stents: experiences with a modified flow-through cell setup. Diss. Technol. 18 (2011) 26-34



A. Neubert, K. Sternberg, S. Nagel, C. Harder, K. P. Schmitz, H. K. Kroemer, W. Weitschies. Development of a vessel-simulating flow-through cell method for the in vitro evaluation of release and distribution from drug-eluting stents. J. Control. Release 130 (2008) 2-8

Diploma theses supervised


Friederike Naumann: Entwicklung einer In vitro-Freisetzungstestmethode zur Charakterisierung von Zubereitungen zur Applikation im subtenonschen Bereich

Jule Niegisch: Herstellung und Untersuchung Modellsubstanz-beschichteter Cochlea-Implantate



Carolin Reschke: Entwicklung von Gelen für die In vitro-Testung der antimikrobiellen Aktivität von endolysinbeschichteten Implantaten mit Knochenmarkkontakt

Christoph Rosenbaum: Entwicklung von Wafern für die Applikation mittels Koronarstents



Vanessa Domsta: Entwicklung von Pantoprazol-haltigen Polymerfilamenten für den 3D-Druck von Tabletten

Anna Marie Baden: Entwicklung eines Spritzenextrusionsverfahrens zur Herstellung 3D-gedruckter Implantate

Tobias Auel: Untersuchungen zum einfluss der Testmethode auf das In vitro-Freisetzungsverhalten von intravitrealen Implantaten

Dana Moritz: Etablierung von Methoden zur Untersuchung des Wirkstofffreisetzungsverhaltens aus goserelin- und leuprorelinhaltigen Depotarzneiformen