Publikationen von Prof. Dr. Patrick J. Bednarski

2020

Behnisch-Cornwell, S., Bandaru, S. S. M., Napierkowski, M., Wolff, L., Zubair, M., Urbainsky, C.,Lillig, Ch., Schulzke, C., Bednarski, P. J. (2020) Pentathiepins: A novel class of glutathione peroxidase 1 inhibitors that induce oxidative stress, loss of mitochondrial membrane potential and apoptosis in human cancer cells. ChemMedChem, 15: 1515-1528. doi:10.1002/cmdc.202000160 (see journal front cover !)

Mbaoji, F.M., Behnisch-Cornwell, S., Ezike, A.C.,Nworu, C.S., Bednarski, P.J. (2020) Pharmacological evaluation of the anticancer activity of extracts and fractions of Lannea barteri Oliv. (Anacardiaceae) on adherent human cancer cell lines. Molecules, 25: 849-868. doi.org/10.3390/molecules25040849

Schepmanna, D., Neuea, Ch., Westphälinger, S., Müller, Ch., Bracher, F, Lange, C., Bednarski, P., Almansa, C., Friedland, K., Räbiger, V., Düfer, M. Wünsch, B. (2020) Pharmacological characterization of high-affinity sigma-1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. Journal of Pharmacy and Pharmacology, 72: 236-248.  doi.org/10.1111/jphp.13196

2019

Makowska, A., Wolff, L. Saczewski, F., Bednarski, P.J., Kornicka, A. (2019) Synthesis and cytotoxic evaluation of benzoxazole/benzothiazole-2-imino-coumarin hybrids and their coumarin analogues as potential anticancer agents. Die Pharmazie, 74: 648-657. doi: 10.1691/ph.2019.9664

Lange, C., Lehmann, Ch., Mahler, M., Bednarski, P.J. (2019) Comparision of cellular death pathways after nTHPC-mediated photodynamic therapy (PDT) in five human cancer cell lines. Cancers, 11: 702. doi:10.3390/cancers11050702

Surur, A.S., Bock, Ch., Beirow, K., Wurm, K., Schulig, L., Kindermann, M.K.,  Siegmund, W.,  Bednarski, P.J., Link, A. (2019) Flupirtine and retigabine as templates for ligand-based drug design of KV7.2/3 activators. Organic & Biomolecular Chemistry, 17: 4512-4522. doi: 10.1039/c9ob00511k

Bock, Ch., Surur, A.S., Beirow, K., Kindermann, M.K., Schulig, L., Bodtke, A., Bednarski, P.J., Link, A. (2019) Sulfide analogues of flupirtine and retigabine with ananomolar Kv7.2/Kv7.3 channel opening activity. ChemMedChem, 14: 952-964.  doi: 10.1002/cmdc.201900112

Behnisch-Cornwell, S., Laubenstein, G., Bednarski, P.J. (2019) Studies of the inhibitor activities of tiopronin and mercaptosuccinic acid on glutatione peroxidase and their cytotoxic and antioxidant properties. Die Pharmazie, 74: 536-542. doi: 10.1691/ph.2019.9472

Surur, A.S., Beirow, K., Bock, C., Schulig, L., Kindermann, M.K., Bodtke, A., Siegmund, W., Bednarski, P.J., Link, A. (2019) Flupirtine analogues: Explorative synthesis and influence of chemical structure on Kv7.2/7.3 channel opening activity. Chemistry OPEN Communications, 8: 41-44. doi: 10.1002/open.201800244

2018

Bock, C., Beirow, K., Surur, A. S., Schulig, L., Bodtke, A., Bednarski, P. J., Link, A. (2018) Synthesis and potassium Kv7 channel opening activity of thioether analogues of the analgesic flupirtine, Organic & Biomolecular Chemistry,  16: 8695. doi: 10.1039/c8ob02530d

Lange, C., Bednarski, P.J. (2018) Evaluation for synergistic effects by combinations of photodynamic therapy (PDT) with temoporfin (mTHPC) and Pt(II) complexes carboplatin, cisplatin or oxaliplatin in a set of five human cancer cell lines, International Journal of Molecular Sciences, 19:  doi: 10.3390/ijms19103183.

Makowska, A., Saczewski, F., Bednarski, P.J., Saczewski, J., Balewski, L. (2018) Hybrid molecules composed of 2,4-diamino-1,3,5 triazines and 2-imino-coumarins and coumarins. Synthesis and cytotoxic properties, Molecules, 23: 1616. doi: 10.3390/molecules23071616

Korcz, M., Saczewski, F., Bednarski, P.J., Kornicka, A. (2018) Synthesis, structure, chemical stability and in vitro cytotoxic properties of novel quinoline-3-carbaldehyde hydazones bearing 1,2,4-triazole or benzotriazole moiety, Molecules 23: 1497. doi.org/10.3390/molecules23061497

Sorenson, B.H., Werth, P., Lambert, I. H.,  Bednarski, P.J. (2018) In vitro evaluation of the enantiomeric R- and S-1,1'-dinaphthyl-2,2'-diaminodichlorido-Pt(II) complexes in human Burkitt lymphoma cells. Emphasis on cellular accumulation, cytotoxicity, DNA binding, and ability to induce apoptosis. Metallomics, 10: 323-336.

Lemmerhirt, H., Behnisch, S., Bodtke, A., Lillig, C., Pazderova, L., Kasparkova, J., Brabec, V., Bednarski, P.J. (2018) Effects of cytotoxic cis- and trans-diammine monochlorido platinum(II) complexes on selenium-dependent redox enzymes and DNA. Journal of Inorganic Biochemistry, 178: 94-105.

Banaschik, R., Jablonowski, H., Bednarski, P.J., Kolb, J.F. (2018) Degradation and intermediates of diclofenac as instructive example for decomposition of recalcitrant pharmaceuticals by hydroxyl radicals generated with pulsed corona plasma in water. Journal of Hazardous Materials, 342: 651-660.

 

2017

Banaschik, R., Lukes, P., Miron, C., Banaschik, R., Pipa, A.V., Fricke, K., Bednarski, P.J., Kolb, J.F. (2017) Fenton chemistry promoted by sub-microsecond pulsed corona plasmas for organic micropollutant degradation in water.  Electrochimica Acta, 245: 539- 548.

Kornicka, A., Saczewski, F., Bednarski, P.J., Korcz, M., Szumlas, P., Romekjko, E., Sakowicz, A., Sitek, L., Wojciechowska, M. (2017) Synthesis and preliminary cytotoxicity studies of 1-[1-(4,5-dihydrooxazol-2-yl)-1H-indazol-3-yl]-3-phenylurea and 3-phenylthiourea derivatives. Medicinal Chemistry, 13: 616-624.

Perfahl, S., Bodtke, A., Pracharova, J., Kasparkova, J., Brabec, V., Cuadrado, J., Stürup, S., Schulzke, C., Bednarski, P.J. (2017) Preparation of bis(5-phenyltetrazolato) Pt(II) and Pt(IV) analogues of transplatin and in vitro evaluation for antitumor activity. Inorganica Chimica Acta, 456: 86-94.

 

2016

Lange, C., Bednarski, P.J. (2016) Photosensitizers for Photodynamic  Therapy: Photochemistry in the service of oncology. Current Pharmaceutical Design, 22: 6956-6974.

Weber, F., Brune, S., Börgel, F., Lange, C., Korpis, K., Bednarski, P.J., Laurini, E., Fermeglia, M., Pricl, S., Schepmann, D., Wünsch, B. (2016) Rigidity versus flexibility: Is this an issue in σ1 receptor ligand affinity and activity? Journal of Medicinal Chemistry, 59: 5505-5519.

Perfahl, S., Natile, M.M., Mohamad, H.S., Helm, C.A., Schulzke, C., Natile, G., Bednarski, P.J. (2016) Photoactivation of diiodido−Pt(IV) complexes coupled to upconverting nanoparticles. Molecular  Pharmaceutics, 13: 2346–2362.

 

2015

Siebel, S., Dammann, C., Sanz Miguel, P.J., Drewello, T.,  Kampf, G., Teubner, N., Bednarski, P.J., Freisinger, E., Lippert, B. (2015) Analogues of cis- and transplatin with a rich colution chemistry: cis-[PtCl2(NH3)(1-MeC-N3)] and trans-[PtI2(NH3)(1-MeC-N3)]. Chemistry: A European Journal, 21: 17827– 17843.

Boge, M., Fowelin, C., Bednarski, P., Heck, J. (2015) Diaminohexopyranosides as ligands in half-sandwich ruthenium(II), rhodium(III), and iridium(III) complexes.Organometallics, 34: 1507-1521.

Scheuch, E., Methling, K., Bednarski, P.J., Oswald, S., Siegmund, W. (2015) Quantitative LC-MS/MS determination of flupirtine, ist N-acetylated and two mercapturic acid derivates in man. Journal of Pharmaceutical and Biomedical Analysis, 102: 377-385.

Ried, M., Lehle, K., Neu, R., Diez, C., Bednarski, P., Sziklavari, Z., Hoffmann, H.S. (2015) Assessment of cisplatin concentration and depth of penetration in human lung tissue after hyperthermic exposure. European Journal of Cardio-Thoracic Surgery, 47: 563-566.

Yellol, J.; Perez, S.A.; Buceta, A.; Yello, G.; Donaire, A.; Szumlas, P.; Bednarsi, P.J.; Makhoufi, G.; Janiak, C.; Espinosa, A.; Ruiz, J. (2015) Novel C,N-cyclometalated benzimidazole ruthenium(II) and iridium(III) complexes as antitumor and antiangiogenic agents: A structure−activity relationship study. Journal of Medicinal Chemistry, 58: 7310-7327.

Navas, F.; Perfahl, S.; Garino, C.; Salassa, L.; Novakova, O.; Navarro-Ranninger, C.; Bednarski, P.J.; Malina, J.; Quiroga, A.G. (2015) Increasing DNA reactivity and in vitro antitumor activity of trans diiodido Pt(II) complexes with UVA light. Journal of Inorganic Biochemistry, 153: 211-218.

Martin-Santos, C.; Michelucci, E.; Marzo, T.; Messori, L.; Szumlas, P.; Bednarski, P.J.; Mas-Balleste, R.; Navarro-Ranninger, C.; Cabrera, S.; Aleman, J. (2015) Gold(III) complexes with hydroxyquinoline, aminoquinoline and quinoline ligands: Synthesis, cytotoxicity, DNA and protein binding studies. Journal of Inorganic Biochemistry, 153: 339-345.

Lemmerhirt, C.J.; Rombach M.; Bodtke A.; Bednarski P.J.; Link, A. (2015) Oxidation potentials of N-modified derivatives of the analgesic rlupirtine linked to potassium KV7 channel opening activity but not hepatocyte toxicity. ChemMedChem, 10: 368-379.

 

2014

Siegmund, W.; Modess, C.; Scheuch, E.; Methling, K.; Keiser, M.; Nassif, A.; Rosskopf, D.; Bednarski, P.J.; Borlak, J.; Terhaag, B. (2014) Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic Nat2, Ugt1a1 and Gstp1. British Journal of Clinical Pharmacology, 79: 501-513.

Korpis, K., Weber, F., Wünsch, B., Bednarski, P.J. (2014) Cytotoxic activities of hydroxyethyl piperazine-based sigma-receptor ligands on cancer cells alone and in combination with melphalan, PB28 and haloperidol. Die Pharmazie, 69: 917-922.

Balewski, L.; Saczewski, F.; Bednarski, P.; Gdaniec, M.; Borys, E.; Makowska, A. (2014) Structural diversity of copper(II) complexes with N-(2-pyridyl)imidazoidin-2-ones(thiones) and their in vitro antitumor Activity. Molecules, 19:17026-17051.

Govender, P.; Lemmerhirt, H.; Hutton, A.T.; Therrien, B.; Bednarski, P.J.; Smith, G.S. (2014) First- and second-generation heterometallic dendrimers containing ferrocenyl−ruthenium(II)−arene motifs: synthesis, structure, electrochemistry, and preliminary cell proliferation studies. Organometallics, 33: 5535-5545.

Weber, F., Brune, S., Korpis, K., Bednarski, P.J., Laurini, E., Dal Col, V., Pricl, S., Schepmann, D., Wünsch, B. (2014): Synthesis, pharmacological evaluation, and σ1 receptor interaction analysis of hydroxyethyl substituted piperazines. Journal of Medicinal Chemistry, 57: 2884-2894.

Wilde, F., Lemmerhirt, H., Emmrich, T., Bednarski, P.J., Link, A. (2014): Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase. Molecular Diversity,  18: 307-322.

Zohrabi-Kalantari, V., Wilde, F., Grünert, R., Bednarski, P.J., Link, A. (2014) 4-Aminocyclopentane-1,3-diols as platforms for diversity: Synthesis of a screening library. Medicinal Chemistry Communications, 5: 203-213.

Korpis, K., Weber, F., Brune, S., Wünsch, B., Bednarski, P.J. (2014) Involvement of apoptosis and autophagy in the death of RPMI 8226 multiple myeloma cells by two enantiomeric sigma receptor ligands. Bioorganic and Medicinal Chemistry, 22: 221-233.

Wilde, F., Chamseddin, C., Lemmerhirt, H., Bednarski, P.J., Jira, T., Link, A. (2014) Evaluation of (S)- and (R)-misonidazole as GPX inhibitors: Synthesis, characterization including circular dichroism and in vitro testing on bovine GPx-1. Archiv der Pharmazie, 346: 1-8, DOI: 10.1002/ardp.201300285 .

 

2013

Bednarski, P.J., Korpis, K., Westendorf, A.F., Perfahl, S., Grünert, R. (2013) Effects of light-activated diazido-PtIV complexes on cancer cells in vitro. Philosophical Transactions A, 371: 20120118.

Balewski, L., Saczewski, F., Gdaniec, M., Bednarski, P.J., Jara, I. (2013) Synthesis of N-(2-pyridyl)imidazoloidin-2-ones and 1-(2-pyridyl)-2,3,7,8-tetrahydro-1H-imidazo[2,1-b][1,3,5]triazepin-5(6H)-ones with potential biological activities. Heterocyclic Communications, 19: 331-341.

 

2012

Kurzwernhart, A., Kandioller, W., Baechler, S., Bartel, C., Martic, S., Buczkowska, M., Mühlgassner, G., Jakupec, M., Kraatz, H.-B., Bednarski, P.J., Arion, V.B., Marko, D., Keppler, B.K., Hartinger, C.G. (2012) Structure-activity relationships of targeted RuII(h6-p-cymene) anticancer complexes with flavonol-derived ligands. Journal of Medicinal Chemistry, 55: 10512-10522.

Schulz, R., Emmrich, T., Behnke, H., Leffler, U., Sydow, K., Hirt, C., Kiefer, T., Link, A., Bednarski, P.J. (2012) Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines. Bioorganic and Medicinal Chemistry Letters, 22: 6712-6715.

Westendorf, A.F., Woods, J.A., Korpis, K. Farrer, N.J., Salassa, L., Robinson, K., Appleyard, V. Murray, K., Grünert, R., Thompson, A.M., Sadler, P.J., Bednarski, P.J. (2012) Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-activated antitumor platinum complex that kills human cancer cells by an apoptosis-independent mechanism. Molecular Cancer Therapeutics, 11: 1894-1904.

Kamper, C., Korpis, K., Specker, E., Anger, L., Neuenschwander, M., Bednarski, P.J., Link, A. (2012) Sustainable synthesis and automated deposition: an accessible discovery screening library of fragment-like purines. Molecular Diversity, 16: 541-551.

Terenzi, A., Ducani, C., Blanco, V., Zerzankova, L., Westendorf, A.F., Peinador, C., Quintela, J.M., Bednarski, P.J., Barone, G., Hannon, M.J. (2012) DNA binding studies and cytotoxicity of a dinuclear PtII diazapyrenium-based metallo-supramolecular rectangular box. Chemistry. A European Journal, 18: 10983-10990.

Hundsdörfer, C., Hemmerling, H.-J., Götz, C., Totzke, F., Bednarski, P., Le Borgne, M., Jose, J. (2012) Indeno[1,2-b]indole derivatives as a novel class of potent human portein kinase CK2 inhibitors. Bioorganic and Medicinal Chemistry, 20: 2282-2289.

Hundsdörfer, C., Hemmerling, H.-J., Hamberger, J. Le Borgne, M., Bednarski, P., Götz, C., Totzke, F., Jose, J. (2012) Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines. Biochemical and Biophysical Research Communications, 424: 71-75.

 

2011

Wasilewska, A., Saczewski, F., Gdaniec, M., Makowska, A., Bednarski, P.J. (2011) Synthesis of highly functionalized tetrahydropyridines with potential biological activity. Archive of Organic Chemistry (ARKIVOC), Part (x): 160-181.

Buczkowska, M. Bodtke, A., Lindequist, U., Gdaniec, M., Bednarski, P.J. (2011) Cytotoxic and antimicrobial activities of Cu(II), Co(II), Pt(II) and Zn(II) complexes with N,O-chelating heterocyclic carboxylates. Archiv der Pharmazie, 344: 605-616.

Riechert-Krause, F., Eick, A., Grünert, R., Bednarski, P.J., Weisz, K. (2011) In vitro anticancer activity and evaluation of DNA duplex binding affinity of phenyl-substituted indoloquinolines. Bioorganic and Medicinal Chemistry Letters, 21: 2380-2383.

Pomarnacka, E., Kornicka, A., Kuchnio, A., Heinrichs, M., Grünert, R., Gdaniec, M., Bednarski, P.J. (2011) Synthesis, cytotoxicity testing and structure activity relationships of novel 6-chloro-7-(4-phenylimino-4H-3,1-benzoxazin-2-yl)-3-(substituted)-1,4,2-benzodithiazine 1,1-dioxides. Archiv der Pharmazie, 344: 431-441.

Grünert, R., Westendorf, A., Buczkowska, M., Hänsch, M., Kühne, S., Bednarski, P.J. (2011) Cytotoxicity Testing-Cell Experiments. In: Metallointercalators (J. Aldrich-Wright, Ed.) Springer Verlag, Wien ( ISBN: 978-3-211-09427-3  ).

Westendorf, A., Bodtke, A., Bednarski, P.J. (2011) Studies on the photoactivation of two cytotoxic trans,trans,trans-diazidodiaminodihydroxo-Pt(IV) complexes. Dalton Transactions, 40: 5342-5351.

Saczewski, J, Gdaniec, M., Bednarski, P.J., Makowska, A. (2011) Synthesis of aza-aromatic hydroxylamine-O-sulfonates and their application to tandem nucleophilic addition-electrophilic 5-endo-trig cyclization. Tetrahedron, 67: 3612-3618.

Westendorf, A., Zerzankova, L., Salassa, L., Sadler, P.J., Brabec, V., Bednarski, P.J. (2011) Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]. Journal of Inorganic Biochemistry, 105: 652-662.

Olszewski, U., Claffey, J., Hogan, M., Tacke, M., Zeillinger, R., Bednarski, P.J., Hamilton, G. (2011) Anticancer activity and mode of action of titanocene C. Investigational New Drugs, 29: 607-614. DOI 10.1007/s10637-010-9395-5 

 

2010

Salassa, L., Ruiu, T., Garino, C., Pizarro, A. M., Bardelli, F., Gianolio, D., Westendorf, A., Bednarski, P. J., Lamberti, C., Gobetto, R., Sadler, P. J. (2010) EXAFS, DFT, Light-Induced Nucleobase Binding, and Cytotoxicity of the Photoactive Complex cis-[Ru(bpy)2(CO)Cl]+. Organometallics, 29: 6703-6710.

Sunnam, S. K., Schepmann, D., Rack, E., Froehlich, R., Korpis, K., Bednarski, P. J., Wuensch, B. (2010) Synthesis and biological evaluation of conformationally restricted s1 receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold. Organic and Biomolecular Chemistry, 8: 5525-5540.

Saczewski, F., Kuchnio, A., Samsel, M., Lobocka, M., Kiedrowska, A., Lisewska, K., Saczewski, J., Gdaniec, M., Bednarski, P.J. (2010) Synthesis of novel aryl(heteroaryl)sulfonyl ureas of possible biological interest. Molecules, 15: 1113-1126.

Reszka, P., Schulz, R., Methling, K., Lalk, M., Bednarski, P.J. (2010) Synthesis, enzymatic evaluation and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem, 5: 103-117. (See journal front cover!)

 

2009

Holl,R., Jung, B., Schepmann, D., Humpf, H-U, Grünert, R, Bednarski P.J.,Englberger, Wünsch, W. (2009) Synthesis and pharmacological evaluation of SNC80 analogues with a bridged piperazine ring. ChemMedChem, 4: 2111-2122.

Mothana R.A.A., Jansen, R., Grünert, R., Bednarski, P.J., Lindequist, U. (2009) Antimicrobial and cytotoxic abietane diterpenoids from the roots of Meriandera benghalesis (Roxb.) Benth. Pharmazie, 64: 613-615.

Kornicka, A., Hudson, A.L., Bednarski, P.J. (2009) Synthesis and biological activity of some 2-imidazolinylhydrazone derivates. Acta Poloniae Pharmaceutica, 66: 523-534.

Krause-Heuer, A.M., Grünert, R., Kühne, S., Buczkowska, M., Wheate, N.J., Le Pevelen, D.D., Boag, L.R., Fisher, D.M., Kasparkova, J., Malina, J., Bednarski, P.J., Brabec, V., Aldrich-Wirght, J.R. (2009) Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicty in human cancer cells. Journal of Medicinal Chemistry, 52: 5474-5484.

Bertrand, H., Bombard, S., Monchaud, D., Talbot, E., Guedin, A., Mergny, J.-L., Grünert, R., Bednarski, P.J., Teulade-Fichou, M.-P. (2009) Exclusive platination of loop adenines in the human telomeric G-quadruplex. Organic and Biomolecular Chemistry, 7: 2864 - 2871.

Olszewski, U., Ach, F., Ulsperger, E., Baumgartner, G., Zeillinger, R., Bednarski, P., Hamilton, G. (2009) In vitro-evaluation of oxoplatin, an oral platinum(IV) anticancer agent. Metal-Based Drugs. Article ID 348916

Hamberger, J., Liebeke, M., Kaiser, M., Bracht, K., Olszewski, U., Zeillinger, R., Hamilton, G., Braun, D., Bednarski, P.J. (2009) Characterisation of chemosensitivity and resistance of human cancer cell lines to platinum (II) versus platinum(IV) anticancer agents. Anti-Cancer Drugs, 20: 559-572.

Mothana, R., Lindequist, U., Grünert, R., Bednarski, P.J. (2009) Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. BMC Complementary and Alternative Medicine, 9: 7.

Willemann, C., Grünert, R., Bednarski, P.J., Troschütz, R. (2009) Synthesis and cytotoxicity activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines. Bioorganic and Medicinal Chemistry, 17: 4406-4419.

Holl, R., Schepmann, D., Fröhlich, R, Grünert, R., Bednarski, P.J., Wünsch, B. (2009) Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on receptor affinity and cytotoxicity. Journal of Medicinal Chemistry, 52: 2126-2137.

Kornicka, A., Bednarski, P.J. (2009) Reaction of 2-chloro-4,5-dihydroimidazole with 1-aminobenzimidazoles: Synthesis of novel fused heterocyclic ring systems. Polish Journal of Chemistry, 83: 693-696.

Mothana, R., Grünert, R., Bednarski, P., Lindequist, U. (2009) Evaluation of the in vitro anticancer, antimicrobial and antioxidant activities of some Yemeni plants used in the folk medicine. Pharmazie, 64: 260-268.

Pomarnacka, E., Kornicka, A., Bednarski, P.J., Charkiewicz, A. (2009) Syntheses of N,S-Substituted 4-chloro-2-mercapto-5-merthylbenzensulfonamide derivatives with potential biological activity. Polish Journal of Chemistry, 83: 65-73.

Mendoza-Ferri, M., Hartinger, C., Mendoza-Parra, M., Groessl, M., Egger, A., Eichinger, R., Mangrum, J., Farrell, N., Maruszak, M., Bednarski, P., Klein, F., Jakupec, M., Nazarov, A., Severin, K., Keppler, B. (2009) Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. Journal of Medicinal Chemistry, 52: 916-925.

Holl, R., Schepmann, D., Bednarski, P.J., Grünert, R., Wünsch, B., (2009) Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma-receptor affinity and cytotoxic activity. Bioorganic and Medicinal Chemistry, 17: 1445-1455.

Holl, R., Schepmann, D., Grünert, R., Bednarski, P.J., Wünsch, B., (2009) Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma-receptor affinity and cytotoxic activity. Bioorganic and Medicinal Chemistry, 17: 777-793.

Methling K., Reszka, P., Lalk, M., Vrana, O., Scheuch, E., Siegmund, W., Terhaag, B., Bednarski, P.J. (2009) Investigations of the in vitro metabolism of the analgesic flupirtine. Drug Metabolism and Disposition, 37: 479-493.

 

2008

Willemann, C., Waibel, R., Grünert, R., Bednarski, P., Troschütz, R. (2008) Unexpected formation of pyridodiindole derivates with cytotoxic activity via double Nenitzescu reaction. Journal of Heterocyclic Chemistry, 45:1517-1519.

Ruf, S., Neudert, G., Gürtler, S., Grünert, R., Bednarski, P.J., Otto, H.-H. (2008) beta-Lactam derivatives as potential anti-cancer compounds. Monatshefte für Chemie, 139: 847-857.

Saczewski, F., Stencel, A., Bienczak, A.M., Langowska, K.A., Michaelis, M., Werel, W., Halasa, R., Reszka, P., Bednarski, P.J. (2008) Structure activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents. European Journal of Medicinal Chemistry, 43: 1847-1857.

Pomarnacka, E., Maruszak, M., Langowska, K., Reszka, P., Bednarski, P.J. (2008) Synthesis and cytotoxicity testing of novel 2-(3-substituted-6-chloro-1,1-dioxo -1,4,2-benzodithiazin-7-yl)-3-phenyl-4(3H)-quinazolinones. Archiv der Pharmazie, 341: 485-490.

Vogel, S., Kaufmann, D., Pojarova, M., Müller, C., Pfaller, T., Kühne, S., Bednarski, P.J., von Angerer E. (2008) Aroyl hydrazones of 2-pheylindole-3-carbaldehydes as novel antimitoic agents. Bioorganic and Medicinal Chemistry, 16: 6436-6447.

Libnow, S., Methling, K., Hein, M., Michalik, D., Harms, M., Wende, K., Flemming, A., Köckerling, M., Reinke, H., Bedanrski, P.J., Lalk, M., Langer, P. (2008) Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines. Bioorganic and Medicinal Chemistry, 16: 5570-5583.

Saczewski, F., Maruszak, M., Bednarski, P.J. (2008) Synthesis and cytotoxic activity of imidazo[1,2-a]-1,3,5-triazine analogues of 6-mercaptopurine. Archiv der Pharmazie, 341: 121-125.

Reszka, P., Methling K., Lalk, M., Xiao, Z., Weisz, K., Bednarski, PJ. (2008) Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry, 19: 49-59.

 

2007

Geiger, C., Zelenka, C., Weigl, M., Fröhlich, R., Wibbeling, B., Lehmkuhl, K., Schepmann, D., Grünert, R., Bednarski, P.J., Wünsch, B. (2007) Synthesis of bicyclic s receptor ligands with cytotoxic activity. Journal of Medicinal Chemistry, 50: 6144-6153.

Pojarová, M., Kaufmann, D., Gastpar, R., Nishino, T., Reszka, P., Bednarski P.J., von Angerer, E (2007) [(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G2/M phase and apoptosis. Bioorganic and Medicinal Chemistry, 15: 7368-7379.

Bracht, K., Kiefer, T., Doelken, G., Bednarski, P.J. (2007) Characterization of three B-cel lymphoma cell lines from chemotherapy resistant patients with respect to in vitro senstitivity to 21 antitumor agents, ABC-transporter experession and cellular redox status. Journal of Cancer Chemotherapy and Clinical Oncology, 133: 957-967.

Saczewski, F., Dziemidowicz-Borys, E., Bednarski, P.J. and Gdaniec, M.(2007) Synthesis, crystal structure, cytotoxic and superoxide dismutase activities of copper(II) complexes of N-(4,5-dihydroimidazol-2-yl)azoles. Archiv der Pharmazie, 340: 333-338.

Brzozowski, Z., Saczewski, F., Slawinski, J., Bednarski, P.J., Grünert, R., Gdaniec, M. (2007) Synthesis, structural characterization, and in vitro antitumor activity of novel N-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)arylsulfonamides. Bioorganic and Medicinal Chemistry, 15: 2560-2572.

Mothana, R.A.A., Grünert, R., Lindequist, U., Bednarski, .PJ. (2007) Study of the anticancer potential of Yemeni plants used in folk medicine. Pharmazie, 62: 305-307.

Fisher, D.M., Bednarski, P.J., Grünert, R., Turner, P., Fenton, R.R., Aldrich-Wright, J.R. (2007) Chiral platinum(II) metallointercalators with potent in vitro cytotoxic activity. ChemMedChem, 2: 488-495.

Bracht, K., Liebeke, M., Ritter, C.A., Grünert, R., Bednarski, P.J. (2007) Correlations between the activities of 19 standard anticancer agents, antioxidative enzyme activities and the expression of ATP-binding cassette transporters: comparison with the National Cancer Institute data. Anti-Cancer Drugs, 18: 389-404.

Bednarski, P.J., Mackay, F.S., Sadler, P.J. (2007) Photoactivatable platinum complexes. Anti-Cancer Agents in Medicinal Chemistry, 7: 75-93. (Review)

 

2006

Bracht, K., Boubakari, Grünert R., Bednarski P.J. (2006) Correlations between the activities of 19 antitumor agents and the intracellular GSH concentrations in a panel of 14 human cancer cell lines: Comparisons with the NCI data. Anti-Cancer Drugs, 17: 41-51.

Bednarski, P.J., Grünert, R., Zielzki, M., Wellner, A., Mackay, F.S., Sadler, P.J. (2006) Light-activated destruction of cancer cell nuclei by platinum diazide complexes. Chemistry and Biology, 13: 61-67 (see Nature Durg Discovery Highlight) .

Saczewski F., Bulakowska, A., Bednarski P. Grünert R. (2006) Synthesis, structure and anticancer activity of novel 2,4-diamino-1,3,5-triazine derivatives. European Journal of Medicinal Chemistry, 41: 219-225.

Pomarnacka, E., Bednarski, P.J., Reszka, P., Dyiemidowicz-Borys, E., Bienczak, A., Werel, W., Halasa, R. (2006) Synthesis and biological activity of new 2-amino-8-chloro-5,5-dioxo[1,2,4]triazolo[2,3-b][1,4,2]benzodithiazines. European Journal of Medicinal Chemistry, 41: 633-639.

Pomarnacka, E., Bednarski, P.J., Grünert, R., Brzozowski, Z., Lach, J. (2006) Synthesis and in vitro cytotoxic activity of novel 6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-ylhydrazine derivatives. Polish Journal of Chemistry, 80: 429-438.

Saczewski, J., Brzozowski, Z., Saczewski, F., Bednarski, P.J., Liebeke, M., Gdaniec, M. (2006) Synthesis and in vitro anti-tumor activity of N--arylsulfonamides. Bioorganic and Medicinal Chemistry Letters, 16: 3663-3667.

Saczewski, F., Dziemidowicz-Borys, E., Bednarski, P.J., Grünert, R., Gdaniec, M., Tabin, P. (2006) Synthesis, crystal structure and biological activities of copper(II) complexes with chelating bidentate 2-substituted benzimidazole ligands. Journal of Inorganic Biochemistry, 100: 1389-1398.

Bose, G., Bracht, K., Bednarski, P.J., Lalk, M., Langer, P. (2006) Synthesis, reactions and structure-activity relationships of 1-hydroxysprio[2.5]cyclooct-4-en-3-ones: Illudin analogs with in vitro cytotoxic activity. Bioorganic and Medicinal Chemistry, 14: 4694-4703.

Dotzauer, B., Grünert, R., Bednarski, P.J., Lanig, H., Landwehr, J., Troschütz, R. (2006) 2,4-Diamino-9H-pyrimido[4,5-b]indol-5-ols: Synthesis, in vitro cytotoxic activity, and QSAR investigations. Bioorganic and Medicinal Chemistry, 14: 7282-7292.

 

2005

Pomarnacka, E., Bednarski, P., Grünert, R., Reszka, P. (2005) Synthesis and anticancer activity of novel 2-amino-4-(4-phenylpiperazino)-1,3,5-traizine derivatives. Acta Poloniae Pharmaceutica, 61: 461-466.

 

2004

Slawinski J., Bednarski P., Reszka P. (2004): Syntheses and in vitro antitumor activity of 3-amino-N-(4-chlorobenzenesulfonyl)guanidine derivatieves containing N'-arylidene moiety. Polish Journal of Chemistry, 78: 369-380.

Saczewski, F., Reszka, P., Gdaniec, M., Grünert, R., Bednarski, P.J. (2004) Synthesis, x-ray crystal structures, stabilities and in vitro cytotoxic activities of new heteroaryl-acrylonitriles. Journal of Medicinal Chemistry, 47: 3438-3449.

Boubakari, Bracht, K., Neumann, Ch., Grünert, R., Bednarski, P.J. (2004) No correlation between GSH levels in human cancer cell lines and the cell growth inhibitory activities of platinum diamine complexes. Archiv der Pharmazie, 337: 668-671.

 

2003

Slawinski J., Bednarski P., Gruenert R., Reszka P. (2003): Syntheses of a new series of N-amino-N¢ -(benzenesulphonyl)guanidine derivatives with potential antitumor activity. Polish Journal of Chemistry, 77: 53-64.

Achilles, K., Bednarski, P.J. (2003): Quantification of elastase-like activity in 13 human cancer cell lines and in an immortalized human epithelial cell line by RP-HPLC. Biololgical Chemistry, 384: 817-824.

Neumann, Ch., Boubakari, Grünert, R., Bednarski, P.J. (2003) Nicotinamide adenine dinucleotide phosphate-regenerating system coupled to a glutathione microtiter method for determination of total glutathione concentrations in adherent growing cancer cell lines. Analytical Biochemistry, 320: 170-178.

Kushev, D., Grünert, R., Spassovska, N., Golovinsky, E., Bednarski, P.J. (2003) Unusual reactivity of cytotoxic cis-dihydrazide Pt(II) complexes in aqueous solution. Journal of Inorganic Biochemistry, 96: 469-477.

 

2001

Rinke, K., Grünert, R., Bednarski, P.J. (2001): New synthetic route to [bis-1,2-(aminomethyl)benzene]dichloroplatinum(II) complexes, screening for cytotoxic activity in cisplatin-sensitive and resistant human cancer cell lines, and reaction with glutathione. Pharmazie, 56: 763-769.

 

1999

Kratochwil, N. A., Parkinson, J. A., Bednarski, P. J. , Sadler,P. J. (1999): Platinierung von Nucleotiden, induziert durch sichtbares Licht. Angewandte Chemie, 111: 1566-1569. (Press release!)

Kratochwil, N. A., Bednarski, P. J. (1999): Relationships between reduction properties and cancer cell growth inhibitory activities of cis-dichloro- and -diiodo-Pt(IV)-ethylenediamines. Archiv der Pharmazie, 332: 279-285.

Kratochwil, N. A., Bednarski, P. J. (1999): Kinetics of thiol-release from human cancer cells and their effects on the stability of Pt(IV)-complexes in culture medium. Journal of Cancer Research and Clinical Oncology, 125: 690-696.

Bednarski, P.J. (1999): JM-216 Johnson Matthey plc. Current Opinion in Oncologic, Endocrine and Metabolic Investigational Drugs, 1: 448-458. (Review)

 

1998

Kratochwil, N. A., Guo, Z., del Socorro Murdock, P., Parkinson, J. A., Bednarski, P. J. , Sadler, P. J. (1998): Electron-transfer-driven trans-ligand labilization: A novel activation mechanism for Pt(IV) anticancer complexes. Journal of the American Chemical Society, 120: 8253-8254 .

 

1997

Mahboobi, S., Dove, S., Bednarski, P.J., Kuhr, S., Burgemeister, Th., Schollmeyer, D. (1997): X-ray crystal structure of woodinine and conformational analysis by semiempircal and 1H-NMR methods. Journal of Natural Products, 60: 587 - 591.

 

1996

Köckerbauer, R., Bednarski, P.J. (1996): Unusual reactivity of cisplatin analogues that bear o-phenylenediamine ligands: Insights for the design of more effective cytotoxic agents. Journal of Inorganic Biochemistry, 62: 281 - 298.

Kratochwil, N.A., Bednarski, P.J., Mrozek, H., Vogler, A., Nagle, J.K. (1996): Photolysis of an iodoplatinum(IV) diamine complex to cytotoxic species by visible light. Anti-Cancer Drug Design, 11: 155 - 171.

Kratochwil, N.A., Zabel, M., Range, K.-J., Bednarski, P.J. (1996): Synthesis and X-ray crystal structure of trans,cis-[Pt(OAc)2I2(en)]: A novel type of cisplatin analog that can be photolyzed by visible light to DNA-binding and cytotoxic species in vitro. Journal of Medicinal Chemistry, 39: 2499 - 2507.

 

1995

Bednarski, P.J. (1995): Reactions of a cisplatin analogue bearing an estrogenic 1,2-diarylethylenediamine ligand with sulfur-containing amino acids and glutathione. Journal of Inorganic Biochemistry, 60: 1 - 19.

Köckerbauer, R., Bednarski, P.J. (1995): A novel approach to preparing water soluble prodrug-forms of cisplatin analogues bearing chelating diamines. Journal of Pharmaceutical Sciences, 84: 819 - 823.

Otto, A.M., Kratochwil, N.A., Eggers, H., Bednarski, P.J. (1995): Chemical stability, biological activity and cellular uptake of a cisplatin analogue having a 1,2-diarylethylenediamine ligand in cultures of human breast cancer cells. Journal of Cancer Research and Clinical Oncology, 121: 31 - 38.

 

1994

Bednarski, P.J., Kratochwil, N.A., Otto, A.M. (1994): Reversible and irreversible interactions of a cisplatin analogue bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro. Drug Metabolism and Disposition, 22: 419 - 427.

Bednarski, P.J., Trümbach, B. (1994): Use of reversed-phase HPLC for the determination of the hydrolysis rate constants of dichloro(1,2-diarylethylenediamine)platinum(II) complexes. Transition Metal Chemistry, 19: 513 - 517.

 

1993

Bednarski,P.J., Hartmann, R. (1993) Synthesis and evaluation of sulfur-containing glutethimide derivatives for aromatase and desmolase inhibitory activity. Archiv der Pharmazie, 326: 391-394.

 

1992

Otto, A.M., Bednarski, P.J., Eggers, H., Trümbach, B., Schönenberger, H. (1992) [meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), an estrogenic Pt(II)- complex for the therapy of breast cancer: relationship between stability and effect. Pharmaceutical and Pharmacological Letters, 1: 103-106.

Müller,R., Bednarski, P.J., Schönenberger, H. (1992) (1,2-Diaryl-1,2-ethylenediamine)platin-um(II) complexes with sulfato and 3-sulfopropionato leaving groups: investigations with differenttypes of coordination in the solid state, in solution and reactions with nucleophiles. Inorganic Chimica Acta, 195: 77-87.

Bednarski,P.J. (1992) Relationships between the aqueous chemistry and the in vitro cytotoxic activities of mixed-amine cisplatin analogues. Biochemical Pharmacology, 43: 2609-2620.

Bednarski,P.J., Trümbach, B., Kratochwil, N.A., Schönenberger, H. (1992) Diamine ligand release from the cisplatin analogue [meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) in cell culture medium. Journal of Medicinal Chemistry, 34: 4479-4485.

 

1991

Bednarski,P.J., Ehrensperger, E., Schönenberger, H., Burgemeister, T. (1991) Aqueous chemistry of mixed-amine cis- and transplatin analogues. Intramolecular preference for a kineticsix-membered ring over a thermodynamic five-membered ring ortho-platination product. Inorganic Chemistry, 30: 3015-3025.

 

1990

Bednarski,P.J., Gust, R., Spruß, T., Knebel, N., Otto, A., Fardel, M., Koop, R., Holler, E., von Angerer, E., Schönenberger, H. (1990) Platinum compounds with estrogen receptor affinity. Cancer Treatment Reviews, 17: 221-231. (Review)

 

1989

Bednarski, P.J., Nelson, S.D. (1989) Dissociation of 19-hydroxy-, 19-oxo-, and aromatizing-activities in human placental microsomes through the use of suicide substrates to aromatase. Journal of Steroid Biochemistry, 32: 309-316.

Bednarski,P.J., Nelson, S.D. (1989) Interactions of thiol-containing androgens with human placental aromatase. Journal of Medicinal Chemistry, 32: 203-213.

 

1985

Silvestri, M.G., Bednarski, P.J., Kho, E. (1985) Stereoselective insertion of the isopropenyl functionality. Journal of Organic Chemistry, 50: 2798-2799.

Bednarski, P.J., Porubek, D.J., Nelson, S.D. (1985) Thiol-containing androgens as suicide substrates of aromatase. Journal of Medicinal Chemistry, 28: 775-779.

 

1984

Nelson,W.L., Bartels, M.J., Bednarski, P.J., Zhang, S., Messick, K., Horng, J.S., Ruffolo, R.R. (1984) The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. Journal of Medicinal Chemistry, 27: 857-861.