Our research group investigates novel modalities in drug discovery and development. We focus on the rational design and development of specialized protein modulators for therapeutic modulation of pathogenic cellular processes. By inducing proximity between a dysregulated target protein and an enzyme (effector), and through the resulting modulation of proteostasis or gene expression, disease processes can be selectively influenced. Our medicinal chemistry research focuses on the following areas:

• Design and development of PROTACs, with a focus on applications in oncology and inflammatory diseases
• Discovery and characterization of novel induced-proximity modalities, such as TCIPs
• Synthesis and biological evaluation of compound libraries, particularly molecular glues
• Physicochemical characterization of drug candidates using biomimetic HPLC methods