Diagnostic electrical biochip

Detection principle

DNA chips (bead-based technology)
Fig. 4. DNA chips (bead-based technology)
Protein chips (array-based technology)
Fig. 5. Protein chips (array-based technology)
Principle of redox-recycling
Fig. 6. Principle of redox-recycling

The detection of nucleic acids (Fig. 4) or proteins (Fig. 5) is in both chip formats achieved by a labelled detection molecule that also binds to the analyte, allowing for binding of a reporter enzyme. The enzyme generates an electrochemically active product that is measured via “redox-recycling” at the electrodes which leads to an electrical signal that corresponds to the amount of detected analyte (Fig. 6).


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